This course provides the concepts and methods of prognostics and health management (PHM). The course describes PHM techniques and their applications in various areas including structural health monitoring (SHM), Integrated Vehicle Health Monitoring (IVHM), Software Health Management (SWHM), and other health monitoring technologies. A variety of tools and techniques for developing health management and monitoring of components and systems will be discussed. This course also include machine learning concepts that identify causal factors to both inform models and the identification of precursors. After successfully completing this course, students will have a good understanding of system health monitoring, optimum sensor placement for health assessment, and current challenges and opportunities in the PHM field.